在极化敏感的光学连贯性断层扫描成像中最小化流动诱导的不确定性,使用自身分解成像
Optics letters
|November 1, 2024
概括
血液流动扰乱了光学连贯断层扫描中的偏振测量. 一种新的固有分解方法将静态和动态信号分开,使底层组织的精确的偏振敏感光学连贯断层扫描 (PSOCT) 成为可能,即使血液流动也存在.
科学领域:
- 生物医学光学 生物医学光学
- 光学连贯性断层扫描技术
- 光子学是指光子学的使用方法.
背景情况:
- 在极化敏感光学连贯断层扫描 (PSOCT) 过程中,血流引入极化测量中的不稳定性.
- 这种不稳定性使得对地下组织属性的分析变得复杂.
- 准确的偏振测量对于各种生物医学应用至关重要.
研究的目的:
- 开发一种方法来克服PSOCT中血流引起的极化不稳定性.
- 为了使血流下面的组织可靠地进行偏振测量.
- 用幻象和体内成像来验证拟议的方法.
主要方法:
- 提出了一种固有分解方法来分离静态和动态的散射信号.
- 使用Intralipid溶液和3D打印的双晶材料的流体幻影被使用.
- 为了证明该方法的实用性,进行了人体指甲的体内成像.
主要成果:
- 固有分解方法成功地分离了静态和动态的散射信号.
- 量化了流量诱导对光轴,相延迟和极化均度的影响.
- 该方法在模拟血流的情况下提供了稳定的偏振测量.
结论:
- 提出的固有分解方法有效地解决了PSOCT中由血液流动引起的极化不稳定性.
- 这种技术提高了地下组织偏振测量的可靠性.
- 该方法对体内应用有前途,正如在人类指甲折叠成像中所示.
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