作为暴露后预防的多西环素:艾滋病毒感染和艾滋病毒风险患者的认识,信念和兴趣
Joshua P Havens1,2, Nathaniel Singh3, Elizabeth Lyden4
1College of Pharmacy, Department of Pharmacy Practice, University of Nebraska Medical Center, 804 S 52nd Street, Omaha, NE, 68198, USA. jhavens@unmc.edu.
AIDS and behavior
|November 1, 2024
概括
大多数患者不知道多西环林暴露后预防 (doxy-PEP) 预防性传播疾病,但表现出兴趣. 临床医生应该与高风险人群讨论doxy-PEP,以改善性病预防策略.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 多西环素暴露后预防 (doxy-PEP) 显示出预防性传播感染 (STIs) 的前景.
- 患者对doxy-PEP的认识,信仰和兴趣在很大程度上尚未得到审查,特别是在性病风险较高的人群中.
研究的目的:
- 评估接受HIV护理或预防 (PrEP) 的成年人对doxy-PEP的认识,信仰,兴趣和担忧.
- 确定与对doxy-PEP的兴趣和担忧相关的因素.
主要方法:
- 在2023年5月至10月期间,对接受HIV治疗或PrEP的166名成年人 (≥19岁) 进行了横截面调查.
- 该调查包括32个关于doxy-PEP意识,信仰,兴趣,担忧,性史和人口统计数据的问题.
- 统计分析包括Fishers Exact,Wilcoxon等级总和测试和多变量后勤回归.
主要成果:
- 大多数受访者 (75%) 没有意识到doxy-PEP.
- 对doxy-PEP的兴趣与被处方PrEP (aOR2.67) 和高性传播感染风险 (aOR4.50) 的信念有关.
- 对doxy-PEP的担忧与年轻的年龄 (≤40岁,aOR 3.10),高等教育 (aOR 3.47) 和高性传播感染风险 (aOR 2.58) 的信念有关.
结论:
- 尽管意识较低,但患者对doxy-PEP表达了兴趣,普遍关注度较低.
- 共同的决策讨论对于向高风险患者提供doxy-PEP至关重要.
- 多克西-PEP 是一种潜在的工具,可以增强风险人群的性病预防策略.
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