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Updated: Jun 8, 2025

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库普弗细胞逆向迁移到肝脏的鼻侧面减轻新生儿败血症和脑膜炎

Bruna Araujo David1,2, Jawairia Atif3,4, Fernanda Vargas E Silva Castanheira1,2

  • 1Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

Science immunology
|November 1, 2024
PubMed
概括

新生儿容易感染,因为肝脏的库弗弗细胞 (KCs) 在产后第一周从肝脏组织迁移到血管. 这种迁移会影响它们清除微生物的能力,影响新生儿的免疫力.

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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