由短,快速起作用的循环利尿剂引起的膀症状:常见但经常被忽视的问题
Christopher S Wilcox1, Negiin Pourafshar1, Karina Han1
1Hypertension Center and Division of Nephrology and Hypertension, Georgetown University, Washington, District of Columbia, USA.
American journal of hypertension
|November 1, 2024
概括
短效循环利尿剂可以使心力衰竭或高血压患者的膀功能障碍 (过度活跃的膀) 恶化. 替代性利尿剂或药物可以改善膀症状和药物坚持.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 膀功能障碍,包括膀过活 (OAB),影响大约15%的美国成年人.
- 在患有充血性心力衰竭 (CHF),高血压,心血管疾病 (CVD) 或慢性病 (CKD) 的患者中,OAB症状的发生率高出2-3倍.
- 只有不到2%的OAB患者寻求治疗,并且担心因利尿剂导致的失禁会导致不坚持.
研究的目的:
- 探索短,快速起作用的循环利尿剂对心血管和共同疾病患者的膀功能障碍的影响.
- 在这些高风险人群中确定用于管理膀功能障碍的替代性利尿策略和药物.
主要方法:
- 进行了文献搜索,以审查现有研究和临床数据.
- 分析利尿剂使用,膀功能和常见的并发症之间的关系.
主要成果:
- 短,快速作用的循环利尿剂可能会加剧OAB症状,原因是膀对快速液体转移的反应.
- 膀功能障碍的这种恶化可能导致药物不服药,以及对高血压等疾病的控制较差.
- 替代治疗方法,包括化物,延长释放环利尿剂或其他类药物可能是有益的.
结论:
- 短效循环利尿剂经常会在患有心血管疾病,心血管疾病,高血压和慢性病的患者中恶化膀功能障碍.
- 这种恶化会损害生活质量和坚持,导致不良结果.
- 考虑替代性利尿剂配方或药物对于管理这些患者的膀功能障碍至关重要.
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