损伤:自身免疫性脑炎的一个被忽视的表现
Zhirong Fan1, Jing Li2, Yingchi Zhang1
1Department of Neurology, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
Journal of neuroimmunology
|November 1, 2024
概括
大约30%的自身免疫性脑炎 (AE) 患者经历损伤,经常在尿液中呈现蛋白质和低白蛋白. 查脏问题对于AE管理至关重要.
科学领域:
- 神经学 神经学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性脑炎 (AE) 是一组神经系统疾病.
- 在AE中,脏的参与并没有得到很好的描述.
- 了解AE中的损伤对于全面的患者护理至关重要.
研究的目的:
- 为了确定AE患者损伤的患病率.
- 描述损伤AE患者的临床特征和相关抗体概况.
主要方法:
- 对AE患者的回顾性分析.
- 在脏参与和脏节约组之间的临床和人口统计数据的比较.
- 尿蛋白,血清白蛋白和脏活检结果的分析.
- 使用威尔科克森等级和试验或奇平方试验进行统计分析.
主要成果:
- 大约30%的AE患者 (32/108) 显示损伤的迹象.
- 常见的发现包括尿蛋白升高,血清白蛋白降低和功能正常.
- 与对照组相比,患有损伤的患者具有较少的抗N-甲基-D-酸盐受体抗体和更多的抗接触素相关蛋白2类抗体.
- 脏活检证实了两个病例的IgA脏病和膜性脏病.
结论:
- 损伤在相当一部分AE患者中是显著的并发症.
- 在治疗自身免疫性脑炎时,应考虑对脏病进行例行查.
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