一个基于瘤微环境响应型PtAu/MnO级纳米反应器的多功能集成纳米平台,具有多酶活性,用于多模式协同瘤治疗
Wenxin Chen1, Dandan Huang2, Ruimei Wu1
1Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350122, China.
Journal of colloid and interface science
|November 1, 2024
概括
一个新的PtAu/MnO2纳米反应器通过耗尽谷,饥饿癌细胞并诱导亡,触发了协同瘤治疗. 这种多功能平台显示出显著的瘤生长抑制,具有出色的生物相容性.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤微环境 (TME) 调制是癌症治疗的关键.
- 单一疗法治疗方法在有效性方面存在局限性.
- 开发用于协同治疗的多功能纳米平台至关重要.
研究的目的:
- 开发一种对TME敏感的PtAu/MnO2级联纳米反应器,用于多式联动瘤治疗.
- 为了提高癌症治疗效果,利用多酶活动.
- 为了研究铁灭,饥饿和化学动力学治疗的综合作用.
主要方法:
- 制造一个PtAu/MnO2级联纳米反应器,对TME因子 (酸度,GSH) 产生反应.
- 使用 PtAu 纳米颗粒进行催化酶,葡萄糖氧化酶和 NADH 氧化酶类活性.
- 研究了纳米反应器诱导铁,饥饿疗法和化学动力学疗法的能力 in vitro 和 in vivo.
主要成果:
- 纳米反应器有效地消耗了谷氨 (GSH),释放了Mn2+和PtAu纳米粒子.
- 通过GSH枯竭诱导的铁灭症实现了协同瘤治疗.
- PtAu NPs产生氧气,耗尽葡萄糖/NADH/ATP用于饥饿疗法,并产生活性氧物种 (ROS).
- Mn2+和PtAu NPs的活性通过化学动力学疗法诱导了亡.
- 证明了出色的生物相容性和显著的瘤生长抑制.
结论:
- PtAu/MnO2级联纳米反应器是一个有前途的多功能平台,用于协同治疗癌症.
- 综合方法有效地结合了铁,饥饿和化学动力学疗法.
- 这种纳米平台提供了一个可行的策略,以克服单一模式癌症治疗的局限性.
关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.铁化是铁化的一种.多功能集成纳米平台.多模式协同的瘤治疗.纳米酶是一种纳米酶.在PtAu/MnO(2) 级联纳米反应器中.这是一种饥饿疗法.更多相关视频
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