响应pH的和zwitterionic菌根细胞增强细胞吸收和抗瘤性能
Lu Zhang1, Yue Shen1, Tiantian Zhang1
1State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China.
Biomaterials advances
|November 1, 2024
概括
研究人员开发了可生物降解的zwitterionic纳米药物 (EK-D-DOX小粒),以减少化疗副作用. 这些菌体表现出增强的瘤向,在酸性环境中释放药物,并在体内改善瘤抑制,具有较低的毒性.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 小分子化疗药物 (SMCD) 引起显著的副作用.
- 现有的纳米药物载体往往具有复杂的合成和缺乏生物降解性.
研究的目的:
- 开发一种适应pH值,可生物降解的zwitterionic纳米药物载体,以克服SMCD的局限性.
- 为了评估多克索鲁比 (DOX) 装载EK-D小粒 (EK-D-DOX) 的疗效和安全性,与免费的DOX和对照组相比.
主要方法:
- 通过点击反应合成pH响应的可生物降解的zwi-terionic分子 (EK-D).
- 封装的多克索鲁比辛 (DOX) 被分成EK-D微粒 (EK-D-DOX) 和准备的对照POO-DOX微粒.
- 评估了小细胞稳定性,蛋白质吸附,体外细胞毒性,药物释放动力学和体内瘤抑制.
主要成果:
- 在pH 7.4下,EK-D-DOX微粒表现出良好的稳定性和低蛋白质吸附性,在pH 5.5.5时聚合.
- 与对照组相比,对EK-D-DOX观察到较高的瘤细胞吸收和细胞毒性.
- 在酸性pH (5.5) 时增强DOX释放,累计释放75.20%.
- 在体内达到95.7%的瘤抑制,毒性降低,血液循环时间延长.
结论:
- EK-D-DOX小粒体代表了一个有前途的生物降解的zwitterionic纳米药物输送系统.
- 响应pH的聚合和药物释放增强了治疗疗效.
- 这种方法为准备更安全,更有效的癌症纳米疗法提供了新的策略.
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