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Updated: Jul 14, 2026

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在患有复发或耐火性非霍奇金淋巴瘤的患者中使用瓦莱梅托斯单疗法:这是首次在人体上进行多中心,开放标签,单臂,第一阶段研究

Dai Maruyama1, Eric Jacobsen2, Pierluigi Porcu3

  • 1Department of Hematology, National Cancer Center Hospital, Tokyo, Japan; Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

The Lancet. Oncology
|November 1, 2024
PubMed
概括

瓦莱梅托斯塔特是一种新型EZH2/EZH1抑制剂,在复发性或耐火性非霍奇金淋巴瘤患者中显示出可接受的安全性和有利的临床活性. 这些发现支持其作为这种患者群体的新治疗选择的潜力.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...