基于活着的脏移植接受者结核病风险因素的伊索尼亚齐德预防:一个回顾性队列研究
Hao Zhang1, Jun Zeng1, Tingting Zhu2
1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
International journal of antimicrobial agents
|November 1, 2024
概括
伊索尼亚 (INH) 预防有效地预防结核病 (TB) 在结核病风险因素的移植接受者. 这种为期6个月的疗法耐受性良好,并且在移植后降低了结核病发病率.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 移植手术 移植手术
背景情况:
- 结核病 (TB) 是固体器官移植受体的重大机会性感染风险.
- 建议在潜在结核病感染时进行预防,但基于风险因素的INH有效性尚不清楚.
研究的目的:
- 根据结核病风险因素,评估脏移植接受者的6个月异化 (INH) 预防方案的有效性和耐受性.
主要方法:
- 一项对1348名脏移植接受者 (2016年1月至2022年12月) 的回顾性研究,根据结核病风险因素和INH使用情况分类.
- 组:具有INH的风险 (R-INH),没有INH的风险 (R-NINH),没有风险 (NR).
- 评估活跃结核病发病率,诊断时间和不良事件.
主要成果:
- 47名患者 (3.49%) 患有结核病. 与NR相比,R-INH在结核病发病率上没有显著差异.
- 与NR相比,R-NINH组的结核病发病率明显较高 (HR 5.04).
- 87%的INH预防完成,副作用最小 (肝毒性,神经炎).
结论:
- 六个月的INH疗法是有效的,并且可以很好地耐受用于预防移植后的结核病,在移植接受者中具有已确定的风险因素.
- 这一策略显著降低了风险人群中的结核病发病率.
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