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通过IgE介导的牛奶过敏的长期结果和持久性的危险因素
Liat Nachshon1, Michael R Goldberg2, Naama Epstein-Rigbi2
1Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir Medical Center, Zerifin, Israel; Department of Medicine, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
许多患有IgE介导的牛奶过敏 (IgE-CMA) 的儿童在青春期时已经超越了这种过敏. 持续性与早期诊断因素有关,但自发解脱甚至在5岁以后也很常见.
科学领域:
- 儿科过敏和免疫学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 之前已经确定了IgE介导牛奶过敏 (IgE-CMA) 解决率在5岁时和持久性风险因素.
- 这项研究扩展了随访,以评估IgE-CMA分辨率和青春期的持续性.
研究的目的:
- 为了确定17岁时IgE-CMA自发分辨率的速度.
- 为了确定与IgE-CMA持续到青春晚期相关的风险因素.
主要方法:
- 对23名IgE-CMA患者的随访研究,这些患者在5岁时仍然过敏,延长到17岁.
- 通过牛奶消费或消极口服食品挑战 (OFC) 评估分辨率;通过反应和皮肤刺伤测试 (SPT) 或高正预测值 (PPV) 敏感化证实过敏.
- 在54名患者的整个队列中分析了持久性风险因素.
主要成果:
- 总体而言,72.2%的患者在17岁时实现了自发解脱.
- 17岁时的持续性与诊断时的SPT>6mm有关,没有早期牛奶配方养,并在初始反应期间喘息.
- 七名患者在5岁以后出现了反应,通常与喘息,过敏反应或当前喘有关.
结论:
- 在5岁以后,IgE-CMA的自发分泌持续到青春期.
- 很少有患者在成年早期出现反应,主要是患有喘的患者.
- 对IgE-CMA的治疗策略应考虑晚期发作的潜在解决方案.
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