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Updated: Jun 8, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
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De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

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翻译复杂配置文件测序允许在上游开放阅读框架控制的翻译中对漏洞扫描和重新启动进行歧视

Dmitri E Andreev1, Jack A S Tierney2, Pavel V Baranov3

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, 117997 Moscow, Russia; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.

Journal of molecular biology
|November 1, 2024
PubMed
概括

本研究引入了翻译复杂分析序列 (TCP-seq) 来分析上游开放阅读框架 (uORF) 以及它们在mRNA翻译中的调节作用. TCP-seq提供了一种新的方法来评估uORF的压制性和机制,而无需报告员构建文物.

关键词:
这是TCP-seqq.有漏洞的扫描扫描.重新启动重新启动里波-seqq 的意思.在 uORF 的情况下.

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