在大脑中,与色素基因相关的的双向功能
Kanheng Lin1, Jacob Stiles2, Willians Tambo3
1Translational Brain Research Laboratory, The Feinstein Institutes for Medical Research, Manhasset, NY, USA; Emory University, Atlanta, GA, USA.
Life sciences
|November 1, 2024
概括
素基因相关 (CGRP) 在大脑中具有双重作用,在缺血期间提供神经保护,但在其他情况下会造成伤害. 了解这种二分法是解锁CGRP的关键.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 素基因相关 (CGRP) 对于血管平衡至关重要.
- CGRP在大脑中表现出相反的效果:在缺血中具有神经保护作用,但在非缺血状态中具有炎症作用.
- 由于缺乏CGRP双模作用的明确决定因素,因此阻碍了其在神经疾病中的治疗用途.
研究的目的:
- 审查CGRP在生理和病理大脑疾病中的多面性作用.
- 确定一个统一的因素,解释CGRP的二分效应.
- 探索增强CGRP在神经疾病中的治疗适用性的策略.
主要方法:
- 关于与CGRP相关的分子通路和细胞反应的综合文献综述.
- 对CGRP对大脑输液的心理影响的分析.
- 调查CGRP上下文影响的因素.
主要成果:
- 升高的CGRP水平在非缺血性疾病中是有害的,但在缺血期间会产生显著的保护作用.
- 这些保护作用包括抗氧化,抗炎,抗丧和血管新生性质,以及行为改善.
- 对于神经退行性疾病,与低 perfusion 相关的心理障碍以及中风后的慢性恢复,CGRP 显示出治疗前景.
结论:
- 阐明CGRP双模性质对于其治疗进步至关重要.
- 在CGRP传递系统和脑缺血检测方面的进展将促进其临床应用.
- 利用CGRP的潜力可以为各种神经病理提供广泛的治疗效益.
更多相关视频
07:28Visualizing the Calcitonin Gene-Related Peptide Immunoreactive Innervation of the Rat Cranial Dura Mater with Immunofluorescence and Neural Tracing
Published on: January 6, 2021
4.0K
07:14Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
2.6K
相关概念视频
00:51Synthesis and Functions of Calcitonin
1.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.6K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
01:16Calmodulin-dependent Signaling
5.1K
Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
5.1K
00:59The Parathyroid Glands
1.9K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.9K
01:27Feedback Regulation of Calcium Concentration
3.4K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.4K
01:21Skeleton and Calcium Homeostasis
4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K