心血管 - - 代谢综合征 - 综合性综述
Katiana Simões Kittelson1, Arquimedes Gasparotto Junior2, Natasha Fillmore3
1Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Brazil; Department of Pharmaceutical Sciences, College of Health and Human Sciences, North Dakota State University, Fargo, ND, United States.
本综述探讨了新出现的生物标志物和炎症在心血管,脏和代谢 (CKM) 综合征中的作用. 了解CKM病理生理学是改善患者治疗结果和整体治疗策略的关键.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 炎症研究的研究.
背景情况:
- 心血管,脏和代谢 (CKM) 综合征涉及这些系统之间的复杂相互作用.
- 了解CKM的病理生理学对于开发有效的预防和治疗策略至关重要.
- 现有的知识差距阻碍了对CKM综合征的最佳患者结果.
研究的目的:
- 确定用于CKM综合征查的新兴生物标志物.
- 阐明炎症在CKM综合征病理生理学中的作用.
- 巩固目前对CKM综合征的理解.
主要方法:
- 在PubMed,Scopus,Web of Science和谷歌学者中进行了广泛的文献搜索.
- 基于标题,摘要和关键词对研究的系统评估.
- 包括38项符合预先定义的资格标准的研究.
主要成果:
- 鉴定了CKM查的潜在生物标志物:血清尿酸,莱普,阿尔多,胆红素,可溶性 neprilysin,利波卡林类型的前列腺素-D-合成酶和内分泌.
- 突出了炎症在CKM综合征病理生理学中的重要作用.
- 提供了关于CKM综合征的背景信息.
结论:
- 新兴的生物标志物显示出早期CKM综合征检测的前景.
- 炎症是CKM综合征发展和进展的关键因素.
- 需要进一步的研究来充分理解和管理CKM综合征.
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