基于豆的银纳米复合物水凝作为药物输送系统和抗菌剂
Amos Luanda1, Manohar Mahadev2, Rompicherla Narayana Charyulu2
1Department of Post-Graduate Studies & Research in Chemistry, Mangalore University, Mangalagangothri, 574199, (DK), Karnataka, India; Department of Chemistry, College of Natural and Mathematical Sciences, University of Dodoma, P.O. Box 338, Dodoma, Tanzania.
International journal of biological macromolecules
|November 1, 2024
概括
一种新型的纳米复合水凝含有豆,聚4-烯基和银纳米颗粒被开发用于持续释放抗癌药物5-fluorouracil (5-FU). 这种材料证明了药物递送的增强和显著的抗菌活性.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 纳米技术 纳米技术
背景情况:
- 有效的药物输送系统对于癌症治疗和对抗感染至关重要.
- 纳米复合材料水凝为控制和向的药物释放提供了有希望的平台.
- 基于豆 (LBG) 和聚4-烯基 (PAcM) 的水凝正在研究它们的药物传递潜力.
研究的目的:
- 合成和描述一种新型的纳米复合材料水凝,其中包括豆 (LBG),聚4-烯基 (PAcM) 和银纳米粒子 (SN).
- 为了评估纳米复合物水凝作为一个聚合物矩阵的持续释放的5-fluorouracil (5-FU),一种抗癌药物.
- 评估纳米复合物水凝的抗菌特性和pH依赖性行为.
主要方法:
- 一种环保的微波 (MW) 辅助方法用于合成LBG/PAcM/SN纳米复合物水凝.
- 使用先进的表征技术来分析合成材料.
- 在实验室中进行了研究,以评估pH依赖性胀,5-FU释放动力学,对黄金葡萄球菌和大肠杆菌的抗菌活性以及使用IEC-6细胞的细胞毒性.
主要成果:
- 在LBG/PAcM/SN纳米复合物水凝中表现出pH依赖的胀和药物释放,在pH 1.2 (模拟的胃液) 与pH 7.4 (模拟的肠液) 相比,在pH 1.2 (模拟的胃液) 释放的5-FU显著更高.
- 在pH 1.2的纳米复合材料中,大约有72%的加载5-FU在3小时内从纳米复合材料中释放出来,而纯凝中的比例为44%.
- 药物释放遵循第一阶级动力学和Fickian扩散. 该纳米复合材料表现出显著的抗菌活性和良好的生物相容性,细胞活力超过80%.
结论:
- 开发的LBG/PAcM/SN纳米复合水凝是一种适合于癌症治疗中持续释放5-FU的矩阵.
- 该纳米复合材料还显示出作为有效抗菌剂的潜力.
- 加入银纳米颗粒显著提高了用于药物输送和抗菌应用的水凝的性能.
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