在转移性激素敏感前列腺癌患者中优化三重疗法
A Borque-Fernando1, D A Pérez-Fentes2, M Rodrigo-Aliaga3
1Servicio de Urología, Hospital Universitario Miguel Servet, IIS-Aragón, Zaragoza, Spain.
Actas urologicas espanolas
|November 1, 2024
概括
结合多塞塔克塞尔,缺乏疗法 (ADT) 和雄激素受体通路抑制剂 (ARPI) 的三重治疗改善了转移性激素敏感前列腺癌 (mHSPC) 的存活率. 本综述指导了基于患者风险和疾病特征的ARPI选择.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 三重治疗 (多克塞尔,ADT,ARPI) 在转移性激素敏感前列腺癌 (mHSPC) 中显示有生存益处,特别是在高风险患者中.
- 当前的指导方针缺乏明确的建议,以选择最佳的ARPI,当ADT和多塞塔克塞尔同时使用.
研究的目的:
- 提供基于证据的指导方针,用于在mHSPC的三重治疗中选择最合适的雄激素受体通路抑制剂 (ARPI).
- 更新关于mHSPC最佳药理治疗的共识,并纳入专家意见.
主要方法:
- 对III期临床试验,系统性审查,元分析和临床实践指南的文献综述.
- 对证据和建议的定性审查,以根据风险,疾病体积和转移时间来指导ARPI选择.
主要成果:
- 三重疗法在mHSPC患者中显示出显著的生存优势.
- 选择ARPI应根据个体患者的风险概况和疾病特征 (体积,同步/转移性转移) 量身定制.
结论:
- 本综述提供了关于在mHSPC的三重治疗中选择ARPI的最新指导.
- 专家的共识支持mHSPC的个性化药物治疗策略.
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