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功能测量与糖尿病中维护比率受损螺旋计之间的关联:NHANES 2007-2012年
Ikramulhaq Patel1, Hong-Jian Gong1, Hui Xu1
1Department of Endocrinology, Beijing Tongren Hospital CMU, Beijing, China.
BMJ open
|November 1, 2024
概括
尿白蛋白与肌素比率 (UACR) 的升高与糖尿病患者的肺功能受损有关. 结合慢性病 (CKD) 和保留比率受损螺旋计 (PRISm) 显著增加死亡风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病是慢性病 (CKD) 的主要原因,也会影响肺功能.
- 功能标志物与肺功能受损的特定模式之间的关系,如保留比率受损螺旋计 (PRISm) 和可变阻塞 (VO),需要进一步调查.
- 评估CKD和肺功能受损对糖尿病患者死亡风险的综合影响对于风险分层和管理至关重要.
研究的目的:
- 在糖尿病患者中调查功能测量 (eGFR,UACR) 和肺功能受损 (PRISm,VO) 之间的关联.
- 评估与糖尿病患者中CKD和肺功能受损并存相关的全因死亡风险.
主要方法:
- 利用了来自国家健康和营养检查调查 (2007-2012) 的数据,其中包括10,809名参与者.
- 使用多变量逻辑回归的横截面分析来检查功能和螺旋计关系.
- 通过使用Cox比例危险模型进行了回顾性队列分析,以评估死亡风险.
主要成果:
- 增加的UACR与更高的PRISm几率显著相关,特别是在糖尿病患者中 (OR=1.21).
- 在糖尿病患者中,UACR≥300 mg/g显著增加了PRISm的几率 (OR=2.34).
- 在患有糖尿病的参与者中,与没有CKD (HR=3.46) 的正常螺旋计相比,同时存在的PRISm和CKD显著增加了全因死亡风险.
结论:
- 升高的UACR和白色素尿与糖尿病患者的PRISm风险增加有关.
- 这项研究强调了糖尿病人群中和肺功能之间的显著相关性.
- 需要进一步的研究来证实这些发现并阐明潜在的机制.
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