在基于多糖的生物纳米复合材料中对微封装Lactobacillus reuteri的活力和稳定性的评估
Mohamadsadegh Mohamadzadeh1, Ahmad Fazeli1, Ebrahim Vasheghani-Farahani2
1Biotechnology Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
Carbohydrate polymers
|November 1, 2024
概括
使用胰岛素,乳和氧化纳米颗粒的微封装增强了益生菌的生存能力. 这种生物纳米复合物保护L. reuteri免受恶劣环境的影响,并提高了保质期.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物材料工程 生物材料工程
- 微生物学 微生物学
背景情况:
- 微封装对于保护细菌免受环境压力因素的保护至关重要.
- 基于多糖的材料为封装提供生物相容的矩阵.
- 纳米粒子可以加强微凝结构,增强保护性质.
研究的目的:
- 为了评估L. reuteriATCC 23272在聚糖基生物纳米复合物中微封装的生存能力.
- 为了优化生物纳米复合物配方使用胰岛素,聚德,乳和氧化纳米颗粒 (MgO NPs).
- 评估微封装系统在模拟胃肠道条件下和储存期间的有效性.
主要方法:
- 使用简单格混合物设计优化生物纳米复合材料组成.
- 结合了胰岛素,多二,pectin作为益生菌和MGONP作为强化剂.
- 使用各种分析技术 (SEM,FTIR,XRD) 评估细菌活力,益生菌评分,挤出效率和稳定性.
主要成果:
- 最佳配方包括91.6%的胰岛素和8.4%的乳素与MGONP.
- 实现了高挤出效率 (97.57%) 和干燥后的可行性 (99.37%).
- 封装的L. reuteri在模拟的胃肠道条件下显著增强活力 (91.74%) 和与自由细胞相比提高存储稳定性.
结论:
- 基于多糖的优化生物纳米复合物在恶劣条件下有效地保护L. reuteri.
- 氧化纳米粒子在增强微凝的保护能力方面发挥着至关重要的作用.
- 这种生物纳米复合体系统有可能改善益生菌的性能和输送.
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