2型糖尿病药物使用趋势和在比利时初级保健中遵守指南 (2019-2023)
Willem Raat1, Pavlos Mamouris1, Chantal Mathieu2
1Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
Primary care diabetes
|November 1, 2024
概括
动脉样性心血管疾病,心力衰竭和慢性病的患病率在比利时2型糖尿病患者中正在增加. 虽然SGLT2抑制剂和GLP-1激动剂等关键药物的使用量有所增加,但许多符合条件的患者仍然没有接受这些药物.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 初级保健研究研究初级保健研究
背景情况:
- 2型糖尿病 (T2D) 是一个日益严重的全球健康问题.
- 患有T2D的患者患上动脉样性心血管疾病 (ASCVD),心力衰竭 (HF) 和慢性病 (CKD) 的风险明显更高.
- 目前的临床指南建议使用特定药物,包括SGLT2抑制剂 (SGLT2-i) 和GLP-1受体激动剂 (GLP-1),用于治疗T2D患者的这些并发症.
研究的目的:
- 为了确定ASCVD,HF和CKD在比利时T2D患者中的患病率.
- 从2019年到2023年分析SGLT2-i和GLP-1激动剂的处方趋势.
- 评估在这个人群中遵守指南推的药物使用情况.
主要方法:
- 对Intego初级保健数据库 (比利时) 的回顾性横截面分析.
- 包括被诊断患有T2D的成年患者.
- 对诊断代码和HbA1c水平进行分析,以识别并发病 (ASCVD,HF,CKD) 和跟踪药物使用 (SGLT2-i,GLP-1).
主要成果:
- 在T2D患者中,ASCVD,HF和CKD的患病率在2023年略有增加,分别达到27%,6.7%和23.7%.
- 在研究期间,SGLT2抑制剂和GLP-1受体激动剂的处方率翻了三倍,到2023年分别达到6.2%和11.5%.
- 尽管增加了,但在2023年,只有7.5%的符合条件的T2D患者被处方这些指南推的药物.
结论:
- 比利时T2D患者面临越来越多的ASCVD,HF和CKD负担.
- 虽然SGLT2抑制剂和GLP-1受体激动剂的使用增加了,但在它们的最佳利用方面存在显著的差距.
- 在初级保健中改善临床指南的实施是必要的,以加强这些高风险T2D患者的管理.
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