相关实验视频

Updated: May 1, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

在COVID-19中,HLA-B -21 M/T二态与疾病严重程度有关

Benedikt Strunz¹, Pouria Momayyezi¹, Eleni Bilev¹

¹Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Genes and immunity

|November 2, 2024

概括

主体遗传学影响COVID-19的严重程度. HLA-B -21 M/T二态影响自然杀手 (NK) 细胞功能,M/M基因型与不太严重的COVID-19相关,并且在住院患者中获得更好的结果.

科学领域:

免疫遗传学免疫遗传学
病毒病原发生的病毒病原体.

背景情况:

宿主基因显著影响免疫反应和传染病严重程度.
HLA-B -21 M/T 模态通过NKG2A受体影响自然杀手 (NK) 细胞的功能.
之前的研究表明NKG2A+NK细胞识别了SARS-CoV-2感染的细胞,但HLA-B二形变异在COVID-19严重性中的作用尚不清楚.

研究的目的:

为了调查HLA-B-21 M/T二形和COVID-19严重程度之间的关联.
分析这种遗传变异对住院未接种疫苗,需要呼吸辅助的患者临床结果的影响.

主要方法:

研究一组230名未接种疫苗的患者住院治疗COVID-19并需要呼吸系统支持.
进行了HLA-B -21 M/T二态的基因型鉴定.
临床数据,包括机械呼吸辅助的需要和实验室参数,与基因型相关分析.

主要成果:

与严重病例相比,中度COVID-19患者中的HLA-B-21M/M基因型更为普遍 (6.0%对0.9%).
患有M/M基因型的患者需要机械呼吸辅助的可能性明显低 (OR = 0.13,P = 0.013).
M/M基因型携带者表现出不同的临床实验室概况和高血清IFN-γ水平.

结论:

这种HLA-B-21 M/T二态性与COVID-19的严重程度有关.
M/M基因型可能会提供对严重疾病的保护,可能是通过增强NKG2A+NK细胞功能和增加抗病毒细胞因子的产生.

更多相关视频

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

相关概念视频

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...