术前血小板分布宽度变化与患有功能衰竭的患者术后急性损伤之间的关联:一项回顾性研究
Yiqi Su1,2,3, Xialian Xu1,4, Zhe Luo5
1Department of Nephrology, Zhongshan Hospital, Fudan University, No 180 Fenglin Rd, Shanghai, China.
BMC nephrology
|November 2, 2024
概括
血小板分布宽度 (PDW) 的变化预测功能障碍患者的心脏手术后急性损伤 (AKI). 增加的PDW表明AKI风险更高,有助于早期检测和管理.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
背景情况:
- 急性损伤 (AKI) 是心脏手术后的严重并发症,特别是在先前存在功能障碍的患者中.
- 血小板分布宽度 (PDW) 是血小板激活的标志物,与病理有关.
- 在这个人群中,PDW变化对AKI风险的预测值需要进一步调查.
研究的目的:
- 评估血小板分布宽度 (PDW) 在术后变化与术后急性损伤 (AKI) 发生率之间的关联.
- 为了确定PDW (dPDW) 的变化是否可以在接受心脏手术的患者中作为AKI的预测因素.
主要方法:
- 对966名患有手术前功能障碍,接受心脏手术的患者进行了回顾性分析.
- 在手术前和ICU入院后测量PDW;计算dPDW.
- 多变量回归和受限立方线分析,以评估dPDW和AKI发病率之间的关联,AKI以KDIGO标准定义.
主要成果:
- 手术后的AKI发生在53.10%的患者中.
- 较高的dPDW是AKI的一个显著的独立风险因素 (OR=1.09,P=0.012).
- 与最低四分位数 (OR=2.95,P<0.001) 相比,dPDW四分位数最高的患者患有AKI的风险几乎高出三倍,与较高dPDW四分位数相比,AKI风险增加的显著趋势.
结论:
- 术后PDW的变化是患有功能衰竭的患者术后AKI的重要预测因素.
- 在这种高风险群体中,dPDW有潜力完善风险分层并指导AKI的管理策略.
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