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对用于中风治疗的基的使用进行了图书统计分析
Garv Bhasin1, Latha Ganti2,3
1Brown University, Providence, RI, USA.
International journal of emergency medicine
|November 2, 2024
概括
丁烯基塑在急性缺血性中风治疗中的使用越来越多,在2023年出版的数量将大幅增加. 然而,它正在等待美国FDA的批准.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 医学文献分析 医学文献分析
背景情况:
- 丁氏甲正在成为治疗急性缺血性中风的阿尔特氏甲的竞争对手.
- 优点包括更容易的管理,更低的剂量,成本效益和有利的安全性.
- 本分析检查了日益增长的学术文献,研究了中风治疗中的基甲.
研究的目的:
- 分析全球学术文献关于使用丁氏甲在治疗急性缺血性中风.
- 确定出版的趋势,主要的研究领域和领先的机构.
主要方法:
- 进行了对Web of Science数据库的系统搜索.
- 在1999年至2023年间发表的文章中使用的关键词是"Tenecteplase"和"Stroke".
- 对576篇文章的元数据分析包括国家,机构,关键词和出版日期.
主要成果:
- 美国 (39.93%) 领先于出版物,其次是澳大利亚 (15.51%),加拿大和中国 (每一个为11.83%).
- 最受欢迎的关键词是甲基,高甲基和血栓溶解.
- 出版物数量在2023年达到顶峰 (24.3%),这表明研究兴趣激增.
结论:
- 2023年出版物的显著增加表明,对中风治疗的丁氏甲基的临床兴趣日益增长.
- 尽管有研究趋势,但tenecteplase尚未获得FDA在美国急性缺血性中风的批准.
- 为了在美国广泛采用,需要采取进一步的监管措施.
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01:29Stroke: Introduction and Types
A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
01:15Ischemic Stroke l: Introduction
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01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
01:17Hemorrhagic Stroke l: Introduction
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01:29Hemorrhagic Stroke ll: Pathophysiology
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