2型糖尿病患者的代谢功能障碍相关的脂肪性肝病:心力衰竭的风险
Rosa Oh1, Gyuri Kim1, Kyu-Na Lee2
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Cardiovascular diabetology
|November 2, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在2型糖尿病患者中增加了心力衰竭和心血管死亡风险. 酒精消费显示了一个J形风险关联,独立于肝病状况.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD) 与2型糖尿病 (T2DM) 患者的心血管结果之间的联系需要进一步澄清.
- 脂肪性肝病 (SLD) 涵盖了一系列由代谢因素,酒精和病毒性肝炎影响的肝病.
研究的目的:
- 调查SLD谱对T2DM患者心力衰竭 (HF) 和心血管 (CV) 死亡风险的影响.
- 为了确定SLD是否是一个独立的风险因素,在这个人群中产生不良心血管结果.
主要方法:
- 一项全国性的队列研究从2009-2012年到2018年跟踪了2,745,689名患有T2DM的成年人.
- 参与者根据代谢风险因素,酒精和病毒性肝炎被分为没有SLD和各种SLD子组.
- 考克斯的比例危险模型被用来评估HF和CV死亡率的风险.
主要成果:
- 患有MASLD,代谢性酒精相关肝病 (MetALD),代谢功能障碍的酒精相关肝病 (ALD与MD) 和病毒性肝炎 (VH) 的MASLD的患病率分别为49.6%,7.2%,2.3%和2.0%.
- 与没有SLD组相比,患有MASLD,MetALD,患有MD的ALD和患有VH的MASLD的个体患高血压风险明显更高.
- 所有SLD群体都显示心血管死亡风险增加,酒精消费与高血压和心血管死亡风险呈J形关联,无论SLD状态如何.
结论:
- 脂肪性肝病 (SLD) 是2型糖尿病患者新发性心力衰竭和心血管死亡的独立风险因素.
- 酒精消费与心力衰竭和心血管死亡率的J形风险曲线有关,独立于SLD的存在或类型.
相关概念视频
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Overview of Lipid Metabolism
1.0K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.0K
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Diabetes: Symptoms, Diagnosis, and Complications
508
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
508
Pathophysiology of Diabetes
872
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
872
Overview of Carbohydrate Metabolism
756
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
756


