三甘油-葡萄糖指数与肥胖指标和中风风险的关联:基于查尔斯数据的纵向研究
Weicai Liang1, Haichun Ouyang2
1The Seventh Affiliated Hospital, Southern Medical University, Liguan Road 28, Foshan, 516006, China.
甘油三糖 (TyG) 指数与体重指数和腰围等肥胖指标相结合,可显著预测中风风险. 这些因素相互影响,改善了超越单独TyG指数的中风预测.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 甘油三糖指数 (TyG) 是胰岛素抵抗的标志物,也是心血管事件的潜在预测指标.
- 泰格指数和肥胖指标 (BMI,WC,WHtR) 对中风风险的综合影响尚未完全理解.
研究的目的:
- 调查中国人口中TyG指数与肥胖指标和中风风险之间的关联.
- 评估联合TyG指数和肥胖指标对中风风险的预测能力.
主要方法:
- 利用来自中国健康与退休长度研究 (CHARLS) (2011-2020) 的17708名参与者 (年龄≥45岁) 的数据.
- 采用了考克斯的比例危险模型,限制立方线 (RCS) 和接收器运行特征 (ROC) 分析.
- 进行了调解分析,以探索TyG指数和中风风险中的肥胖指标之间的相互作用.
主要成果:
- 综合指标 (TyG-BMI,TyG-WC,TyG-WHtR) 显示出与中风风险有显著的积极关联.
- TyG-WHtR和TyG-WC显示了对中风的最高预测能力 (AUC:0.696).
- 在55岁以上的个人和男性中,相关性更强;TyG和肥胖指标相互调解了他们与中风的关系.
结论:
- 与TyG指数与肥胖指标相结合,与单独的TyG指数相比,大大提高了中风风险预测.
- 肥胖指标和TyG指数在中风风险的发展中发挥着相互调解的作用.
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