术前单剂量静脉注射维生素C对关节全整形术后疼痛的影响
Guangtao Han1, Yanfeng Gan2, Qin Wang1
1West China hospital of sichuan university, Sichuan, Chengdu, China.
Journal of orthopaedic surgery and research
|November 2, 2024
概括
维生素C补充剂在全关节置换术 (THA) 后减少了吗啡使用和疼痛评分. 虽然没有达到临床意义,但它在短期内改善了疼痛和部功能.
科学领域:
- 整形外科手术 整形外科手术
- 疼痛管理 疼痛管理
- 营养科学 营养科学
背景情况:
- 关于维生素C对关节置换术后疼痛的疗效的研究有限.
- 已知维生素C可以缓解手术后其他疾病的疼痛.
研究的目的:
- 为了研究维生素C在经过全关节整形术 (THA) 后的疼痛管理中的有效性.
主要方法:
- 一项前性,双盲,安慰剂控制,随机化试验,涉及100名THA患者.
- 在手术期间,患者接受了3g的静脉注射维生素C或安慰剂.
- 吗啡被用作救援止痛药,通过视觉模拟尺度 (VAS) 评估疼痛和部恢复.
主要成果:
- 维生素C组在手术后24小时显示了减少的吗啡需求和较低的VAS疼痛得分.
- 维生素C组在24小时后观察到部运动的改善.
- 然而,观察到的改善没有达到预定义的临床重要差异最小值.
结论:
- 静脉注射维生素C,作为多模式止痛的一部分,增强了THA后的疼痛缓解和功能恢复.
- 在THA患者中,单次的外科维生素C剂量可能足以进行最佳的疼痛管理.
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