Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.5K
Genomics02:02

Genomics

36.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dupilumab in Difficult-to-treat Chronic Spontaneous Urticaria: A Real-world Multicentre Cohort Study.

Acta dermato-venereologica·2026
Same author

Optimizing the use of patient-reported outcome measures in axial spondyloarthritis: a mixed-methods study from the QUESTIONAX Project.

Seminars in arthritis and rheumatism·2026
Same author

Revisiting the Role of Antibiotics in Hidradenitis Suppurativa in the Biologic Era.

The Australasian journal of dermatology·2026
Same author

Early identification of difficult-to-manage axial spondyloarthritis using machine-learning decision trees.

Therapeutic advances in musculoskeletal disease·2026
Same author

Clinical Features of Hidradenitis Suppurativa in Down Syndrome Patients: A Multicenter Spanish Study.

Journal of cutaneous medicine and surgery·2026
Same author

PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity.

Science advances·2026

相关实验视频

Updated: Jun 8, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K

从一个多米范围的Hidradenitis Suppurativa.

Patricia Garbayo-Salmons1, Ester Saus2, Vicente Exposito-Serrano1

  • 1Dermatology Department, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT-CERCA), Universitat Autònoma de Barcelona, Sabadell, Spain.

Journal of cutaneous medicine and surgery
|November 2, 2024
PubMed
概括

补腺炎 (HS) 是一种全身免疫媒介疾病. 综合遗传学,蛋白质学,微生物组和代谢学的研究表明,了解HS病理学和开发个性化治疗是有前途的.

关键词:
遗传学 遗传学 遗传学 是一个性炎是一种补充性性炎.微生物组是一个微生物组.俄米克斯 (Omics) 是一个电子产品.蛋白质组学 蛋白质组学

更多相关视频

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

389
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.2K

相关实验视频

Last Updated: Jun 8, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

1.4K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

389
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.2K

科学领域:

  • 免疫学 免疫学 免疫学
  • 遗传学 遗传学 是一个
  • 微生物组研究 微生物组研究
  • 代谢学 代谢学 代谢学

背景情况:

  • 补腺炎 (HS) 是一种慢性炎症性皮肤疾病.
  • HS与其他免疫媒介疾病 (IMIDs) 有共同的特征.
  • 在将omics数据与HS的临床发现相关联时存在挑战.

研究的目的:

  • 审查和综合HS的遗传学,蛋白质学,微生物组和代谢学研究的发现.
  • 通过整合多omics数据来探索HS的潜在病因.
  • 确定HS的潜在生物标志物和治疗点.

主要方法:

  • 对鉴定信号通路 (Notch,炎症体) 和综合性HS突变的遗传研究进行审查.
  • 蛋白质组数据的分析揭示了炎症途径和免疫激活.
  • 检查微生物组研究显示皮肤和肠道微生物群的失生症.
  • 评估指标改变了代谢途径的代谢概况.

主要成果:

  • 遗传学研究涉及Notch信号,炎症酶功能障碍和综合征性HS (PAPA,PASH) 的特定突变.
  • 蛋白质组学突出了激活的先天性和适应性免疫.
  • 微生物组分析显示,病变中的Prevotella增加和S. epidermidis减少;肠道失生症涉及R. gnavus和C. ramosum.
  • 代谢学表明托和脂质代谢的调节失调,细菌代谢物参与.

结论:

  • 尽管取得了进展,但HS中强大的多经济学协会仍然难以捉摸.
  • 整合多样化的OMIC数据集对于识别新的HS表型和遗传倾向至关重要.
  • 整合这些数据集的未来研究可以导致新的生物标志物和HS的个性化治疗策略.