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开发和验证一个模型来预测谁可以从HCC患者的多重TACE中受益

Huizhi Zhang¹, Xingxing Wang¹, Hongxiang Wang¹

¹Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.

Clinical and experimental medicine

|November 2, 2024

概括

这项研究开发了一种预测模型,以识别多重透气管动脉化学栓塞 (TACE) 的受益者肝细胞癌 (HCC) 患者. 该模型准确地预测了治疗反应,有助于HCC管理的临床决策.

科学领域:

肝胆道医学肝胆道医学
干预性放射学干预性放射学
在瘤学瘤学.

背景情况:

肝细胞癌 (HCC) 是一种主要的肝癌,治疗选择有限.
过导管动脉化学栓塞 (TACE) 是对不可切除的HCC的常见息治疗方法.
预测对多次TACE会话的反应对于优化患者的治疗结果至关重要.

研究的目的:

开发和验证一种预测模型,用于识别从多种TACE治疗中受益的HCC患者.
识别与连续TACE程序的积极结果相关的独立风险因素.
为了改善患者选择TACE疗法在HCC.

主要方法:

使用后勤回归分析开发和验证预测模型.
将228名患者纳入开发组和98名患者纳入验证组.
使用ROC曲线,校准曲线和决策曲线评估模型性能.

主要成果:

完整的瘤包裹,肝叶参与,瘤数量和α-fetoprotein (AFP) 水平被确定为独立的危险因素.
该模型在开发集中达到0.843的AUC,在验证集中达到0.828.
校准和决策曲线分析证实了该模型的良好预测能力.

结论:

一个经过验证的模型有效地预测哪些HCC患者将从多种TACE治疗中受益.
鉴定到的风险因素提供了对HCC的TACE反应的见解.
这种预测模型可以帮助临床医生选择适合TACE治疗的候选人.

关键词:

福利福利福利福利肝细胞癌 (HCC) 是一种肝细胞癌.这个名字叫做Nomogram.预测模型是一个预测模型.通过导管动脉化学栓塞 (TACE)

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