忽视了通过绿潮扩散传播抗微生物耐药性的传播风险
Yanhui Zhao1, Jian Zhang2, Yu Zheng3
1Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science & Engineering, Shandong University, Qingdao 266237, PR China.
Water research
|November 2, 2024
概括
来自Enteromorpha开花的绿色潮在海洋环境中显著增加了抗生素耐药性基因 (ARG). 这些花作为主要来源,将ARG和耐药病原体传播到周围的水域,造成生态和公共卫生风险.
科学领域:
- 海洋微生物学 海洋微生物学
- 环境科学环境科学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 绿色潮,特别是来自Enteromorpha的绿色潮,带来了由气候变化和环保变化加剧的环境问题.
- 这些繁殖可能会影响抗生素耐药细菌 (ARB) 和抗生素耐药基因 (ARG) 的传播.
- 虫在抗菌素耐药性 (AMR) 的分布和传播中的精确作用尚未完全理解.
研究的目的:
- 调查ARG配置文件,它们的动态组成,以及相关的健康风险.
- 为了分析Enteromorpha生物圈内的ARG和南黄海海湾周围的海水.
- 确定植物界对海洋抗体的贡献,并确定相关风险.
主要方法:
- 在Enteromorpha生态圈和周围海水之间对ARG丰度和多样性的比较分析.
- 源追踪和元基因组分析以确定ARG的来源.
- 对包括ESKAPE病原体在内的耐药病原体的量化,以及对水平基因转移 (HGT) 潜力的评估.
主要成果:
- 类生物的生态圈显示出明显更高的ARG丰富性,但其多样性低于周围的海水.
- 源源追踪证实了自然界是周围海水抗体的主要贡献者.
- 耐药性病原体,特别是具有HGT潜力的ESKAPE病原体,在自然界中更为普遍.
结论:
- 形动物的开花显著增强了海洋生态系统中ARG和耐药病原体的传播.
- 植物圈充当高风险ARG的储存和传播者,将其传播到周围的水域.
- 形虫繁殖对健康和生态存在重大抗菌素耐药性风险,需要对海洋环境中的抗菌素耐药性负担采取公共卫生视角.
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