阻塞性睡眠呼吸暂停与使用rSUDEP-7的性突发意外死亡 (SUDEP) 风险有关
Atiwat Soontornpun1, Christian Mouchati2, Noah D Andrews2
1Sleep Disorders Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand.
Epilepsy & behavior : E&B
|November 2, 2024
概括
患有和中度/重度阻塞性睡眠呼吸暂停 (OSA) 的成年人具有更高的SUDEP风险得分. 建议对这些患者进行常规的OSA查,以潜在地减轻SUDEP风险.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 中突然意外死亡 (SUDEP) 是管理中的一个重要问题.
- 阻塞性睡眠呼吸暂停 (OSA) 是成年患者 (AWE) 的常见并发症.
- OSA和SUDEP风险之间的关联需要进一步调查.
研究的目的:
- 评估聚睡眠学 (PSG) 确认的OSA和SUDEP风险之间的关系.
- 使用修订后的SUDEP风险清单 (rSUDEP-7) 来量化SUDEP风险.
- 评估中度/严重的OSA是否与AWE中较高的SUDEP风险得分有关.
主要方法:
- 在2004-2016年间接受了PSG的成年患者 (AWE) 的回顾性分析.
- 由呼吸暂停-呼吸暂停指数 (AHI) ≥5/h定义的OSA;中度/严重的OSA是AHI ≥15.
- 使用rSUDEP-7评估SUDEP风险;用Wilcoxon等级总和测试和多变量线性模型分析关联,对共变量进行调整.
主要成果:
- 在62.6%的AWE中存在OSA;中度/重度OSA在35%.
- 患有中度/重度OSA (AHI ≥15) 的AWE具有显著更高的rSUDEP-7得分 (中位数为3对1,p=0.001).
- 更高的AHI和氧气不和指数 (ODI) 与rSUDEP-7得分正相关.
结论:
- 患有和中度/重度OSA的成年人,特别是患有泛性强力-克隆性的老年人,表现出更高的SUDEP风险得分.
- 这些发现支持在所有患有的成年人中进行OSA常规查.
- 需要进一步的研究来证实OSA对SUDEP风险的影响.
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