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在炎症性肠道疾病中亚临床粉样蛋白沉积:一项两家医院的研究
Yuichiro Hamamoto1, Kansuke Kido2, Michihiro Kawamura3
1Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Department of Diagnostic Pathology, Daini Osaka Keisatsu Hospital, Osaka, Osaka, Japan.
Pathology, research and practice
|November 2, 2024
概括
亚临床粉样蛋白沉积在炎症性肠病 (IBD) 患者中很罕见,克罗恩病中发现了一个病例. 建议在具有复杂病史的老年IBD患者中早期检测amyloidosis.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 内部医学 内部医学
背景情况:
- 炎症性肠病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),通常影响年轻人,并可能导致肠道并发症.
- 氨基粉症,以异常的蛋白质聚合为特征,是IBD的罕见但严重的并发症,早期检测对于预防严重后果至关重要.
- 目前缺乏针对IBD患者亚临床粉样蛋白沉积物的例行调查.
研究的目的:
- 追溯调查诊断为IBD的成年患者中亚临床粉样蛋白沉积的患病率.
- 分析手术样本是否存在粉样沉积物,并将发现与临床信息相关联.
主要方法:
- 从两个医院数据库中收集了249名成人IBD患者 (131名CD,118名UC) 的手术样本.
- 标本经过刚果红色染色和免疫组织化学检测粉样蛋白检测.
- 同时收集所有参与患者的临床信息.
主要成果:
- 在克罗恩病 (1131名患者中1名) 中观察到0.8%的总体粉样蛋白阳性率.
- 在性结肠炎患者中没有检测到粉样蛋白沉积物 (118人中0人).
- 唯一的阳性病例涉及一位有肠切除史和腹部症状的老年女性,被确定为粉样蛋白A亚型.
结论:
- 在成人IBD患者中,亚临床的粉样蛋白沉积很少发生,特别是在UC.
- 这些发现强调了在老年IBD患者中考虑粉样粉症的重要性,IBD患者具有长期和复杂的临床病史.
- 对这种特定的患者亚组,积极的粉样蛋白分析可能是有益的.
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