围神经侵袭和喉状细胞癌:一个系统的审查
Debora Modelli Vianna Ocampo Quintana1, Rogerio Aparecido Dedivitis2, Luiz Paulo Kowalski2
1Hospital Heliópolis, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
Brazilian journal of otorhinolaryngology
|November 2, 2024
概括
在喉癌中,周围神经侵袭 (IPN) 是一个负面的预后因素. 这一元分析证实了IPN的存在.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 围神经侵入 (IPN) 是各种癌症中公认的特征.
- 由于研究结果相互矛盾,其在喉癌的预后意义仍在争论中.
研究的目的:
- 进行元分析,最终确定IPN在喉癌的预后价值.
- 巩固现有的关于IPN与喉癌患者结局关系的证据.
主要方法:
- 在主要数据库 (PubMed,Scielo,Lilacs,Cochrane,Websco) 进行了全面的文献审查.
- 使用RevMan 5.4软件进行了统计分析.
- 在分析中包括了19项喉癌研究.
主要成果:
- 围神经侵袭 (IPN) 与0.71 (95% CI:0.590.86) 的2年生存相对风险 (RR) 有关.
- 在IPN的存在下,无病生存率显示RR为0.51 (95%CI:0.141.95).
- 局部区域性复发表明,IPN的RR增加了1.71 (95% CI: 1.252.35).
结论:
- 周围神经侵袭 (IPN) 被证实是喉癌的显著负面预后因素.
- IPN的存在与较差的生存率和更高的局部区域复发率相关.
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