步行节奏与中风风险的关联:在欧洲祖先队列中进行了一项两样本的门德尔随机化研究
Cong Liang1, Xinlin Huang2, Yucui Pu3
1School of Nursing, University of South China, Heng Yang, 421001, China; Yellow River Centre Hospital of the Yellow River Conservancy Commission, Zheng Zhou, 450000, China.
缓慢的步行速度 (WP) 因果上增加了中风风险. 识别较慢WP的个体可以帮助早期干预和中风预防策略.
科学领域:
- 遗传学 遗传学 是一个
- 流行病学 流行病学
- 心血管健康 心血管健康
背景情况:
- 步行节奏 (WP) 是一个关键的生理指标,与各种健康结果有关.
- 脑卒中带来了高发病率,残疾和死亡率,需要有效的预防策略.
- WP与中风风险之间的因果关系需要进一步阐明.
研究的目的:
- 为了确定步行速度和中风风险之间的因果关系.
- 使用两个样本的门德尔随机化 (MR) 方法.
- 在欧洲祖先的人口中调查这一关联.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 利用了来自FinnGen (n=284,040) 的中风GWAS数据和来自英国生物银行 (n=459,915) 的WP GWAS数据.
- 应用了反变量加权 (IVW),MR-Egger和加权中位数方法,并对变性和异质性的灵敏度分析.
主要成果:
- 确定了48个单核酸多态 (SNPs) 作为有效的仪器变量.
- 发现较慢的步行节奏与较高的中风风险因果相关 (OR = 0.573;P = 0.007).
- 灵敏度分析证实了结果的稳定性和可靠性,没有检测到显著的性或异质性.
结论:
- 该MR研究提供了证据,证明WP与中风风险之间存在逆因果关系.
- 步行速度较慢是中风的因果风险因素.
- 建议对WP较慢的个体进行及时的体检和有针对性的干预,以减轻中风风险并改善生活质量.
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