维生素D对阿佩林/APJ系统的激活减弱了与年龄相关的肌肉缩
Yoo Jeong Lee1, Gyu Hee Kim1, Da Som Lee1
1Division of Endocrine and Kidney Disease Research, Department of Chronic Disease Convergence Research, National Institute of Health, Cheongju 28159, Republic of Korea.
Life sciences
|November 2, 2024
概括
维生素D补充剂逆转了与年龄相关的肌肉损失,并改善了小鼠的肌肉健康,模仿了运动的好处. 这表明维生素D是预防与年龄相关的代谢疾病的潜在干预措施.
科学领域:
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
- 营养科学 营养科学
背景情况:
- 衰老导致肉症,其特点是肌肉质量和力量下降,通常由减少体力活动加剧.
- 维生素D因其在肌肉健康中的作用越来越受认可,但其精确的分子机制,特别是关于衰老的机制,仍在研究中.
- 肌基因是肌肉产生的信号分子,与肌肉平衡和与年龄相关的变化有关.
研究的目的:
- 调查维生素D3补充剂对抗老年肌肉缩和老化在小鼠中的有效性.
- 探索维生素D对肌肉的影响背后的分子机制,重点关注肌蛋白调节和细胞衰老标志物.
- 为了比较维生素D补充剂与运动对与年龄相关的肌肉衰减的影响.
主要方法:
- 年轻和年长的C57BL/6小鼠被分为三个组:对照饮食,维生素D3补充饮食和正常饮食与运动,持续4个月.
- 评估了肌肉的力量和质量.
- 分析了肌肉缩,细胞衰老和肌激素表达 (包括阿佩林,APJ,IL-6和GDF8) 的分子标志物.
主要成果:
- 维生素D3补充剂有效地逆转了与年龄相关的肌肉力量和质量的下降.
- 肌肉缩和细胞衰老的标志物在接受维生素D3的老年小鼠中显著减少.
- 在接受维生素D3补充饮食的老年小鼠中,阿佩林及其受体 (APJ) 的表达增加,类似于运动效应. 在老年小鼠中 IL-6 和 GDF8 的循环水平升高,通过维生素D3 治疗得到正常化.
结论:
- 维生素D3补充改善老化诱导的肌肉缩和老化在小鼠.
- 维生素D3对肌肉健康的影响与运动的影响相当.
- 维生素D可以作为一种有价值的干预策略,用于预防与肌肉衰退相关的与年龄相关的代谢疾病.
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