重用阿普雷皮坦:除了其抗作用之外,它可以防止多克索鲁比辛诱导的化学脑膜吗?
Asmaa A Gomaa1, Dalaal M Abdallah2, Hanan S El-Abhar3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ahram Canadian University, 6(th) of October City, Giza, Egypt.
阿普雷皮坦是一种NK-1R抑制剂,对多克索鲁比诱导的化学脑产生神经保护作用. 它提高了认知能力,并减少了海马体的炎症,氧化应激和亡.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 物质P (SP) 和神经素-1受体 (NK-1R) 轴在病理过程中起作用.
- 阿普雷皮坦是一种NK-1R阻断剂,在化疗期间用作抗药.
- 阿普雷皮坦在缓解多克索鲁比 (DOX) 诱导的化学脑的疗效尚未完全被理解.
研究的目的:
- 调查阿普雷皮坦对DOX诱导的化学脑的神经保护潜力.
- 阐明阿普雷皮坦效应的潜在分子机制.
主要方法:
- 采用了一种DOX诱导的化学大脑大鼠模型.
- 用行为测试评估认知功能.
- 分析了海马体形态,分子标记物 (SP,NF-κB,IL-1β,分裂的酶-3,MDA,谷氨,BCL-2),miR-146a和ER压力路径.
主要成果:
- 在DOX治疗的老鼠中,阿普雷皮坦改善了认知缺陷和海马体形态.
- 阿普雷皮坦减少了SP,NF-κB,IL-1β,切割了caspase-3,malondialdehyde和miR-146a的表达.
- 阿普雷皮坦增加了谷氨和Bcl-2水平,并抑制了PERK/eIF-2α/ATF-4/CHOP内质网膜压力级联.
结论:
- 阿普雷皮坦对DOX诱导的化学脑产生神经保护作用.
- 这些效应通过缓解炎症,氧化和亡反应来调解.
- 阿普雷皮坦的机制包括减少SP,ER压力和miR-146a,为化学大脑提供潜在的治疗策略.
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