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相关概念视频

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Liver Histology01:27

Liver Histology

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
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相关实验视频

Updated: Jun 8, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
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脂肪酸性肝病

Mads Israelsen1, Sven Francque2, Emmanuel A Tsochatzis3

  • 1Centre for Liver Research and Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Lancet (London, England)
|November 2, 2024
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概括

脂肪酸性肝病,包括代谢功能障碍相关的脂肪酸性肝病 (MASLD) 和与酒精有关的肝病 (ALD),是肝硬化的主要原因. 早期发现纤维化和新疗法可以降低死亡率.

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科学领域:

  • 肝病学和胃肠病学
  • 代谢疾病
  • 公共卫生

背景情况:

  • 脂肪性肝病 (SLD) 具有异常的肝脂肪积累特征,包括与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精有关的肝病 (ALD).
  • 在欧盟和美国,SLD是肝硬化的主要病因,全球影响率为30%,主要原因是肥胖,2型糖尿病和酒精.
  • 由炎症驱动的肝纤维化进展是SLD中肝脏相关死亡的主要预测因素.

研究的目的:

  • 审查最近的脂肪性肝病重新分类及其对临床实践和预后的影响.
  • 在初级保健和专家之间提出早期肝纤维化诊断的协作框架.
  • 讨论目前的管理策略,治疗目标和MASLD的药物开发.

主要方法:

  • 关于SLD分类,诊断和治疗的最新进展的文献综述.
  • 对SLD和肝硬化的流行和影响的流行病学数据的分析.
  • 对MASLD的纤维化检测和治疗管道新兴生物标志物的审查.

主要成果:

  • 在SLD的重新分类提供了一个更完整的临床和预后框架.
  • 纤维化生物标志物和治疗方法的进步有可能降低与SLD相关的发病率和死亡率.
  • 建议采用协作诊断方法来改善早期发现肝纤维化.

结论:

  • 牛脂性肝病及其更新的分类需要全面的治疗方法.
  • 通过合作框架及早发现肝纤维化对于改善患者的治疗结果至关重要.
  • 目前正在进行的研究和药物开发有望治疗MASLD并减少SLD相关的肝硬化负担.