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Updated: May 10, 2026

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呼吸道上皮的实时成像显示,粘膜干净度调节SARS-CoV-2的传播

Mark E Becker1, Laura Martin-Sancho2, Lacy M Simons3

  • 1Department of Cell & Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Nature communications
|November 3, 2024
PubMed
概括

粘膜细胞清除 (MCC) 最初有助于SARS-CoV-2在呼吸道中传播. 然而,由粘液驱动的MCC的晚期恶化最终限制了病毒的传播,揭示了复杂的相互作用.

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...