在未接种疫苗的固体器官移植接受者中,SARS-CoV-2感染和严重的COVID-19的危险因素
Casper Vrij1,2, Kris Bogaerts3, Pieter Vermeersch4,5
1Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Scientific reports
|November 3, 2024
概括
在未接种疫苗的固体器官移植接受者中,基线皮质类固醇使用,而不是其他免疫抑制剂,与严重的COVID-19有关. 感染的其他危险因素包括糖尿病和肺部疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 移植 移植 移植 移植
背景情况:
- 免疫抑制疗法对未接种疫苗的固体器官移植 (SOT) 接受者的SARS-CoV-2感染和COVID-19严重性的影响尚不清楚.
- 评估感染和严重结果的风险因素对于管理这种脆弱人群至关重要.
研究的目的:
- 调查基线免疫抑制疗法与其他风险因素与未接种疫苗的SOT接受者的SARS-CoV-2感染和严重的COVID-19之间的关联.
- 在这个队列中确定SARS-CoV-2感染和严重的COVID-19的独立预测因子.
主要方法:
- 在2020年7月至2021年4月期间,分析了1957名未接种疫苗的SOT接收者的队列.
- 进行了多变量分析,以确定SARS-CoV-2感染和严重的COVID-19的风险因素.
- 严重的COVID-19被定义为需要补充氧气,ICU入院或导致死亡.
主要成果:
- 感染SARS-CoV-2的发生率为12.6% (247/1957),其中23.1% (57/247) 患有严重的COVID-19.
- 感染SARS-CoV-2的独立风险因素包括糖尿病,慢性肺病和与COVID-19阳性个体接触.
- 免疫抑制疗法和感染风险之间没有发现任何关联.
- 严重的COVID-19独立地与高血压,慢性病,皮质类固醇使用和患有COVID-19阳性室友有关.
结论:
- 基线皮质类固醇使用,但不是其他免疫抑制剂,在未接种疫苗的SOT接受者中独立与严重的COVID-19有关.
- 这些发现凸显了在这个人群中与皮质类固醇相关的特定风险,并强调了针对性预防策略的必要性.
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