患有非结核性真菌菌原发性皮肤感染:报告了6例病例
Qi-Hao Yao1,2, Hui-Lin Zhi1, Xiu-Jiao Xia1
1Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
BMC infectious diseases
|November 3, 2024
概括
原发性皮肤非结核菌菌感染,存在非特异性皮肤病变. 早期诊断和治疗会导致良好的预后,即使是难以识别的菌株.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 非结核菌 (NTM) 感染的发病率增加,特别是皮肤表现.
- NTM皮肤感染代表着一个显著且日益增长的临床挑战.
研究的目的:
- 描述一次性皮肤NTM感染的临床特征和微生物学发现.
- 在案例系列中分析诊断挑战和治疗结果.
主要方法:
- 六例被诊断为原发性皮肤NTM感染的病例的回顾性分析.
- 对临床数据,微生物学的结果和病原体学的综述.
- 培养和元基因组学下一代测序 (mNGS) 发现的比较.
主要成果:
- 所有六个病例都是原发性皮肤NTM感染,创伤或免疫抑制是潜在的触发因素.
- 红斑结节性皮肤病变是主要的表现.
- 鉴定出了Mycobacterium marinum,M. abscessus和M. avium;mNGS与培养的一致性有限.
- 大多数患者对口服药物反应良好,表明预后良好.
结论:
- 皮肤NTM感染的临床表现通常是非特异性的,使诊断复杂化.
- 微生物识别可能具有挑战性;mNGS需要仔细重新评估.
- 怀疑具有治疗反应不佳的非典型感染可能表明潜在的免疫抑制.
- 及时诊断和治疗对于有利的结果至关重要.
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