在NSAIDs中的损伤:基于FAERS数据库的真实世界分析
Haojie Xu1, Jiaming Cao1, Hongyi Zhang2
1Guangzhou Hospital of Integrated Traditional and Western Medicine Affiliated to Guangzhou University of Chinese Medicine, Guangzhou, 510800, China.
International urology and nephrology
|November 3, 2024
概括
非类固醇抗炎药 (NSAIDs) 携带损伤的风险,特别是在老年患者中. 布洛芬显示损伤的风险报告最高,而塞莱科克西布的风险最低,大多数事件发生在治疗的早期.
科学领域:
- 药物监督 药物监督 药物监督
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药品安全 药品安全
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 广泛用于治疗疼痛和炎症.
- 无 NSAID 与各种不良事件有关,包括损伤.
- 了解不同NSAIDs的比较风险概况对于患者安全至关重要.
研究的目的:
- 评估与NSAID使用相关的损伤报告风险.
- 为了比较报告中的五种不同NSAID的风险水平和发病时间.
- 为了确定患有NSAID诱导损伤风险较高的患者群体.
主要方法:
- 一项利用FAERS数据库 (2004-2023) 的药监测研究.
- 使用报告几率比率 (ROR) 和贝叶斯信心传播神经网络 (BCPNN) 检测损伤的信号.
- 五种NSAID的发病率,死亡率和发病时间的比较:伊布罗芬,切莱科克西布,阿司匹林,纳普罗森和迪克洛芬雅克.
主要成果:
- 老年患者面临NSAID相关损伤的风险增加.
- 布洛芬的报道频率 (46.7%) 和损伤信号 (ROR 3.3) 是最高的.
- 塞莱科克西布报告频率 (7.3%) 和信号 (ROR 1.4) 最低;阿司匹林死亡率最高 (18.7%).
- 损伤的中位发病时间为6天,79.3%发生在使用30天内.
结论:
- 布洛芬对损伤的信号最高,而赛莱科克西布的信号最低.
- 老年人更容易受到NSAID诱导的损伤.
- 与NSAID相关的损伤通常在治疗的早期表现出来,需要仔细监测患者.
- 这些发现强调了在临床实践中对NSAID相关的脏风险需要保持警.
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