功能性大脑网络在临床高风险的双相情感障碍和精神病
Cemal Demirlek1, Burcu Verim2, Nabi Zorlu3
1Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
大脑网络中断在临床高风险精神病 (CHR-P) 个体中是明显的,与临床高风险双相情感障碍 (CHR-BD) 和健康对照人群不同. 这些网络变化与精神病症状相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 异常的大脑连接与严重的精神疾病,如双相情感障碍和精神分裂症有关.
- 了解高危人群中的功能性大脑网络对于早期干预至关重要.
研究的目的:
- 调查大规模的功能性大脑网络和全球网络指标在临床高风险的双相情感障碍 (CHR-BD),临床高风险的精神病 (CHR-P),和健康的对照 (HCs).
- 探索功能网络变化与风险青年精神病相关症状之间的关系.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 用于从CHR-BD (n=25),CHR-P (n=30) 和HCs (n=19) 获得脑部扫描.
- 应用了图形理论分析和基于网络的统计数据来检查全脑网络拓和连接模式.
主要成果:
- 与HC相比,CHR-P个体在视觉,默认模式,突出和 cingulo-opercular网络之间表现出更强的连接性,以及在默认模式内的连接性以及在默认模式和fronto-parietal网络之间降低的连接性.
- 与CHR-BD相比,CHR-P显示总效率降低,而CHR-BD和HC之间没有发现显著差异.
- 全球效率与高危人群中低于值的积极症状和思维障碍有负相关.
结论:
- 这些发现表明,与HC和CHR-BD相比,CHR-P中功能性大脑网络存在明显的干扰.
- 超诊断性精神病特征与风险青少年的功能性脑网络改变有关.
- 由于样本大小和药物状态,结果是探索性的,需要进一步调查.
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