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无线矩阵金属蛋白酶-9传感通过智能伤口包裹与控制的抗菌纳米颗粒释放到慢性伤口管理

Peixue Deng¹, Zhenghan Shi², Feiyue Fang³

¹Life Sciences Institute, Guangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Medical University, Nanning, Guangxi, 530021, PR China; Taizhou Key Laboratory of Medical Devices and Advanced Materials, Research Institute of Zhejiang University, Taizhou, 318000, PR China.

Biosensors & bioelectronics

|November 3, 2024

概括

一种新的智能伤口包裹可以监测矩阵金属蛋白酶-9 (MMP-9) 并提供抗菌治疗. 这种无线,灵活的设备有助于慢性伤口管理,并显示出个性化患者护理的前景.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
伤口护理技术伤口护理技术

背景情况:

慢性伤口带来了重大的健康和经济挑战.
有效的管理需要持续的监测和有针对性的治疗.
目前的伤口评估和治疗方法往往是侵入性的,缺乏实时反.

研究的目的:

开发一种无线,灵活的智能伤口带,用于监测矩阵金属蛋白酶-9 (MMP-9) 水平.
为了有效的慢性伤口管理,纳入抗菌能力.
允许在现场进行伤口分析和个性化治疗策略.

主要方法:

使用带有生物活性的生物反应性水凝制造一个高度敏感的射频MMP-9传感器.
传感器与灵活的感应电容 (LC) 电路集成,用于无线监控.
在可降解水凝中将银纳米颗粒 (AgNPs) 纳入,以控制抗微生物的释放.
使用糖尿病足 (DFU) 患者的伤口排泄物对金标准光测量进行MMP-9检测准确性的验证.

主要成果:

开发的智能伤口包裹展示了无线和可穿戴功能,用于现场伤口分析.
基于水凝的传感器显示MMP-9检测的高灵敏度.
控制释放的AgNP提供了对大肠杆菌和金黄色葡萄球菌有显著的抗菌疗效.
在DFU患者排泄物中实现了准确的MMP-9量化,与光测定相对应.

结论:

成功开发了一种新的无线和灵活的智能伤口包裹.
该包裹可以同时监测MMP-9和对慢性伤口进行抗菌治疗.
这项技术在推进个性化伤口管理方面具有重大潜力,特别是在DFU等疾病中.

关键词:

水凝是一种水凝.矩阵金属蛋白酶-9传感器银纳米颗粒银纳米粒子聪明的伤口包裹伤口包裹可以穿戴的电子产品.

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