伴随性疾病及其与多发性硬化症患者群体结局的关联:快速审查
Hanna A Frank1, Melissa Chao1, Helen Tremlett2
1School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Multiple sclerosis and related disorders
|November 3, 2024
概括
伴随性疾病显著影响多发性硬化症 (MS) 的结果,抑郁症和等疾病与更严重的残疾和更高的死亡率有关. 管理这些同时出现的疾病对于MS患者的护理至关重要.
科学领域:
- 神经学 神经学
- 公共卫生 公共卫生
- 临床研究 临床研究
背景情况:
- 多发性硬化症 (MS) 经常伴有大量的并发性疾病负担.
- 单个并发症对MS相关残疾,治疗开始和死亡率的具体影响需要全面调查.
研究的目的:
- 系统地审查和综合现有证据,研究伴随性疾病与残疾之间的关联,治疗的开始和MS患者的死亡率.
主要方法:
- 对2002年1月至2023年10月期间发表的研究进行了快速审查.
- 在MEDLINE,Embase和灰色文献中搜索相关研究.
- 系统地提取数据并使用既定标准评估偏差风险.
主要成果:
- 包括100项主要研究,检查88种并发病;大多数人群是30-45.5岁的女性 (60-80%).
- 抑郁症和与增加的残疾和死亡率有着一致的关联.
- 糖尿病与增加的死亡率有关,但残疾关联不一致;焦虑-残疾联系是可变的.
结论:
- 伴随性疾病显著影响MS的结果,精神病,代谢和神经系统疾病带来更高的风险.
- 针对性地管理并发症对于改善多发性硬化症进展,残疾和死亡率至关重要.
- 预防和治疗并发症是综合性多发性硬化患者护理的组成部分.
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