在急性缺血性中风患者中,表型年龄和加速衰老与严重程度和残疾的关联
Yongkang Liu1, Jiangchuan Wang1, Zicheng Wei1
1Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
The journal of nutrition, health & aging
|November 3, 2024
概括
生物年龄,以表型年龄 (PhenoAge) 衡量,与更大的急性缺血性中风严重程度和残疾有关. 加快的衰老预示着更糟糕的结果,即使考虑到时间表年龄,强调其在中风风险评估中的重要性.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 生物年龄,比时间年龄更准确地预测健康结果,与急性缺血性中风 (AIS) 相关的研究不足.
- 现型年龄 (PhenoAge) 和加速衰老代表了关键的生物年龄指标.
- 了解生物年龄和AIS严重程度之间的关联对于风险分层和管理至关重要.
研究的目的:
- 调查PhenoAge,加速衰老,以及AIS后的严重程度和残疾之间的关联.
- 为了比较PhenoAge的预测能力与计时年龄,评估中风的结果.
主要方法:
- 一项回顾性研究涉及936名AIS患者 (2019-2021) 和512名患者 (2022-2023) 的验证队列.
- 使用国家卫生研究院中风量表 (NIHSS) 评估中风严重程度;通过修改的兰金量表评估残疾.
- 使用时间年龄和9个临床化学生物标志物计算PhenoAge;进行了后勤回归分析.
主要成果:
- PhenoAge独立地与中风严重程度的增加有关 (NIHSS ≥5和≥10).
- 加速衰老显著增加中度至重度中风和严重残疾的可能性.
- 与时间学年龄相比,PhenoAge对中风严重程度的预测能力更强 (NIHSS ≥5的AUC为0.66和0.61).
结论:
- 老化和加速衰老显著与AIS患者中风严重程度和残疾增加有关.
- 这些发现表明,生物年龄指标在预测AIS结果时提供了超越时间年龄的宝贵见解.
- 这些结果强调了PhenoAge作为评估中风风险和预后的生物标志物的潜力.
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