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构建一个不良结果路径框架,以了解母亲暴露于PM_2.5对后代肝脏发育和损伤的影响

Kexin Zhang¹, Li Tian¹, Qinglin Sun¹

¹Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China; Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, China.

Environmental toxicology and pharmacology

|November 3, 2024

概括

母亲接触细颗粒物 (PM2.5) 可能会损害新生儿肝脏发育. 本综述使用不良结果路径框架来解释PM2.5如何导致新生儿肝损伤.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

环境细颗粒物 (PM2.5) 是一个主要的空气污染物,对公共健康有重大影响.
越来越多地认识到母亲暴露于PM2.5对胎儿发育的潜在不良影响.
肝脏,其关键的代谢和分泌功能,是一个关键的器官,其发展可能会受到影响.

研究的目的:

阐明母亲PM2.5暴露与新生儿肝损伤之间的机制联系.
应用不良结果路径 (AOP) 框架来了解发育性毒性.
为未来的研究和预防策略提供有关PM2.5暴露和肝脏健康的见解.

主要方法:

使用不利结果路径 (AOP) 框架进行分析.
审查了有关PM2.5,氧化应激和肝脏发育的现有文献.
综合信息从分子到人口水平.

主要成果:

孕产妇暴露于PM2.5可能会引发过度反应性氧物种 (ROS) 生成和内质网膜 (ER) 压力.
这些分子事件可以导致氧化应激,DNA损伤,自功能障碍和子孙的线粒体损伤.
AOP框架有效地展示了从PM2.5暴露到新生儿肝损伤的途径.

结论:

母亲的PM2.5暴露存在新生儿肝损伤和发育异常的风险.
AOP框架为了解PM2.5发育毒性的机制基础提供了有价值的工具.
本次审查强调了在怀孕期间减轻PM2.5暴露的战略的必要性,以保护后代的肝脏健康.

关键词:

负面结果的途径.发展性毒性发展性毒性肝脏肝脏肝脏肝脏孕产妇暴露的母亲暴露.氧化应激是一种氧化应激.在PM中{2.5)

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