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Updated: Jun 8, 2025

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向纤维细胞激活蛋白与化学抗原受体巨细胞

Yizhi Mao1, Chen Yao1, Shimeng Zhang1

  • 1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China.

Biochemical pharmacology
|November 3, 2024
PubMed
概括

针对纤维细胞激活蛋白 (FAP) 的工程巨细胞在治疗癌症和肝纤维化方面表现有前途. 在小鼠模型中,FAP-CAR-ΔZETA巨体表现出显著的抗瘤作用和改善肝纤维化.

关键词:
这就是CAR-Ms.在CRC中,CRC就是CRC.在 FAP FAP 里面.免疫治疗是一种免疫疗法.肝脏纤维化 肝脏纤维化发细胞症 (phagocytosis) 是一种致死细胞的发生.

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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