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胰岛素通过调节 lipopolysaccharide-challenged brojlers 中的微生物群来缓解炎症反应和肠道屏障功能障碍

Qinghui Shang¹

¹Poultry Institute, Shandong Academy of Agricultural Sciences, Jinan 250100, China.

International journal of biological macromolecules

|November 3, 2024

概括

胰岛素补充剂保护肉免受脂聚糖 (LPS) 诱导的炎症和肠道屏障损伤. 它通过调节肠道微生物群和增强有益细菌来实现这一目标,改善肉的整体健康.

科学领域:

动物科学动物科学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

肉中的脂聚糖 (LPS) 挑战会导致全身炎症并损害肠道屏障功能.
免疫应激会对肉生长和生产效率产生负面影响.
研究饮食干预措施以减轻LPS诱导的负面影响.

研究的目的:

研究胰岛素对LPS诱导的炎症和肠道屏障功能障碍的保护作用.
评估胰岛素对脑内微生物群组成和代谢物产生的影响.
评估胰岛素在缓解LPS引起的生长迟缓方面的作用.

主要方法:

108只肉被分为对照组,LPS挑战组和用胰岛素补充LPS挑战组.
通过腹膜内注射诱导LPS挑战.
采集了血液,肠道粘膜和肠道消化器的样本进行分析.

主要成果:

这种LPS的挑战导致了促炎性细胞因子的增加和肠道屏障的损坏.
胰岛素补充剂通过抑制TLR4和NF-κB p65激活来减轻LPS诱导的炎症.
胰岛素调节的细胞微生物群,增加有益的细菌 (例如,Faecalibacterium) 和短链脂肪酸 (例如,丁酸盐).

结论:

食胰岛素部分缓解LPS诱导的炎症和肉肠道屏障损伤.
胰岛素的益处是通过调节肠道微生物群和代谢物生产来实现的.
胰岛素显示出减轻免疫应激和改善 brojiler 生产增长的潜力.

关键词:

肉牛肉是什么意思炎症炎症是一种炎症.肠道屏障的功能是肠道屏障.在这种情况下,胰岛素和胰岛素是不同的,而胰岛素和胰岛素是不同的.脂聚糖类糖化物脂聚糖类糖化物微生物群中的微生物群

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