在领先的牙科期刊上发表的随机对照试验中选择性结果报告:一项研究对研究的研究
Yutong Wang1, Feiyang Guo2, Xiyuan Chen1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, PR China.
Journal of dentistry
|November 3, 2024
概括
选择性结果报告 (SOR) 在超过一半的牙科随机对照试验 (RCT) 中被发现. 这种在主要期刊中普遍存在的偏见,可以扭曲证据合成并影响临床决策.
科学领域:
- 牙科研究 牙科研究
- 临床试验 临床试验
- 生物统计学 生物统计学
背景情况:
- 选择性结果报告 (SOR) 是一种偏见形式,可以影响研究结果的解释.
- 了解牙科中SOR的流行率和驱动因素对于确保证据可靠性至关重要.
研究的目的:
- 确定在顶级牙科期刊上发表的随机对照试验 (RCT) 中选择性结果报告 (SOR) 的流行率.
- 在牙科RCT中识别与SOR相关的因素.
主要方法:
- 进行了2018-2023年在领先的牙科期刊上发表的RCT的手动搜索.
- 对具有注册和定义初级结果的RCT进行了分析,以查找注册和发布之间的差异,包括初级结果,样本规模和资金.
- 一个概括的估计方程模型被用来识别与SOR相关的因素.
主要成果:
- 在270个纳入RCT中的51.5%中发现了选择性结果报告 (SOR).
- 最常见的SOR表现是初级结果评估时间上的差异 (31.9%).
- 与SOR相关的重要因素包括样本大小,注册时间和随访时间的差异.
结论:
- 选择性结果报告 (SOR) 是在著名牙科期刊上发表的随机对照试验 (RCT) 中广泛存在的问题.
- 研究人员和利益相关者之间需要提高意识和协作努力,以提高牙科的结果报告质量.
- 解决SOR对于防止误导读者,扭曲证据综合和影响临床决策至关重要.
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