嗅觉神经母细胞瘤和嗅觉癌症:一个实际的审查
Michael W Mikula1, Lisa M Rooper2
1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Surgical pathology clinics
|November 3, 2024
概括
嗅觉神经母细胞瘤 (ONB) 和嗅觉癌瘤 (OC) 是具有神经外皮分化的鼻腔瘤. 本综述阐明了它们的独特特征和诊断挑战,有助于将它们与其他小型圆形蓝细胞瘤区分开来.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
背景情况:
- 鼻道内有两个由神经外皮分化引起的初级瘤:嗅觉神经母细胞瘤 (ONB) 和嗅觉癌瘤 (OC).
- ONB的特征是质蛋白阴性瘤,具有球状结构和可变的神经纤维质矩阵.
- 最近确定的一种实体OC具有质素阳性神经皮质细胞,通常与腺体结构相交.
研究的目的:
- 提供对ONB和OC的临床和诊断特征的全面概述.
- 阐明区分ONB和OC之间的关键特征,以及区分它们与其他鼻腔小圆蓝细胞瘤的关键特征.
- 为准确诊断和鼻道差异诊断提供实际指导.
主要方法:
- 文献综述侧重于临床表现,组织病理学发现和ONB和OC的免疫组织化学概况.
- 对ONB,OC和其他相关鼻瘤的诊断标准的比较分析.
- 讨论重叠的特征和潜在的诊断陷.
主要成果:
- ONB和OC是不同的神经外皮瘤,具有不同的角质蛋白表达和建筑模式.
- 两个实体都可能具有重叠的特征,需要仔细评估.
- 不同诊断必须考虑其他神经内分泌表达小圆蓝细胞瘤的鼻区域.
结论:
- 准确区分ONB和OC对于适当的患者管理至关重要.
- 了解特定的组织病理学和免疫组织化学标志物对于诊断至关重要.
- 本综述是临床医生和病理学家管理鼻腔神经外皮瘤的实用指南.
相关概念视频
01:25Olfaction
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
01:03Olfactory Receptors: Location and Structure
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
01:20Physiology of Smell and Olfactory Pathway
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...