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韩国犬类细菌性角膜炎中的细菌分离物和抗生素敏感性
Jiwoo Park1, Donghee Kim1, Myeongjee Kwon1
1Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea.
Veterinary ophthalmology
|November 3, 2024
概括
多抗药性细菌,主要是葡萄球菌,在韩国犬类细菌性角膜炎中很常见. 有效的治疗需要仔细选择抗生素,并探索可持续的替代方案来对抗日益增长的耐药性.
科学领域:
- 兽医眼科医生 兽医眼科医生
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 狗的细菌性角膜炎是狗的一种重要的眼睛疾病.
- 抗微生物药物耐药性的增加对有效治疗提出了挑战.
- 了解当地的细菌菌群和敏感性模式对于兽医眼科至关重要.
研究的目的:
- 分析来自韩国犬类细菌性角膜炎的细菌分离物.
- 确定抗生素敏感性模式,重点关注多药性耐药性 (MDR).
- 为临床管理确定有效的抗生素组合.
主要方法:
- 从146只可疑患有细菌性角膜炎的狗身上采集了157个眼睛样本.
- 使用矩阵辅助激光吸附/电离飞行时间 (MALDI-TOF) 隔离和识别细菌.
- 通过最小抑制度 (MIC) 和评估的组合疗法进行了抗生素敏感性测试.
主要成果:
- 在55.4%的样本中分离出来的细菌; 葡萄球菌 (48.5%),链球菌 (13.1%), Pseudomonas (9.1%) 和大肠杆菌 (9.1%) 是最常见的.
- 阿米卡辛的敏感性很高 (84.8%),而多西环素的敏感性很低 (17.2%).
- 在52.5%的隔离物体中观察到多药性耐药性 (MDR);阿米卡-莫西素是最有效的组合 (93%).
结论:
- 葡萄球菌种类普遍存在,MDR的发病率很高,这凸显了需要制滥用抗生素的需要.
- 储备抗生素,如阿米卡辛,用于耐药性感染,以防止进一步的耐药性.
- 将重点转向细菌性角膜炎的可持续替代治疗方法,以减少对抗生素的依赖.
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