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在青少年皮肤肌肉神经炎的失脂症
Amer Khojah1, Gabrielle Morgan2, Arya Kadakia2
1Department of Pediatrics, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
青少年皮肤肌肉炎 (JDM) 患者经常患有脂质不良症,特别是低HDL和高甘油三. 较低的HDL水平与较高的疾病活性相关,特别是在以前没有接受过治疗的儿童中.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 在自身免疫性疾病中的心血管健康
- 慢性疾病中的代谢综合征.
背景情况:
- 青少年皮肤肌炎 (JDM) 是一种罕见的自身免疫性疾病,影响儿童.
- 脱脂症是心血管疾病的已知危险因素.
- 在JDM中失脂症和疾病活性之间的关系尚未得到充分证实.
研究的目的:
- 为了确定JDM患者中脱脂症的患病率.
- 调查血脂不良与JDM疾病活动指标之间的关联.
- 在这个人群中识别出潜在的失脂血症风险因素.
主要方法:
- 追溯查看142名患有禁食脂质样本的JDM患者的表格.
- 在脂质评估时收集疾病活动的临床和实验室标志物.
- 统计分析以将脂质参数与疾病活动指标相关联.
主要成果:
- 在JDM患者中高患病率 (72%) 的异常或边界脂质谱.
- 低HDL和高甘油是最常见的脂质异常.
- 较低的HDL水平与增加的疾病活性评分 (DAS总数,肌肉,皮肤),新素,ESR和vWF Ag.显著相关.
- 与接受药物治疗的患者相比,以前没有接受过治疗的患者显示HDL水平明显降低.
结论:
- 患有JDM的患者表现出高血脂不良的负担,与疾病活动密切相关.
- 低HDL和高甘油是JDM的关键脂质异常.
- 建议每年对JDM患者进行脂质监测和早期干预.
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