具有多个前核的高比例的囊胚在常规试管婴儿中增加了胚胎多核化率
Mingzhao Li1, Xia Xue1, Juanzi Shi2
1The ART Center, Northwest Women's and Children's Hospital, Xi'an, China.
Scientific reports
|November 3, 2024
概括
在体外受精过程中,高比例的多核前核 (≥3PN) 异构体与双细胞阶段 (MN2) 多核发生率的增加有关. 然而,MN2胚胎类型会影响胚胎细胞形成率,有助于胚胎选择.
科学领域:
- 生殖生物学 生殖生物学
- 胚胎学 胚胎学
- 在体外受精 (IVF)
背景情况:
- 升高的雌激醇 (E2) 水平和增加的卵细胞检索与较高的多个前核 (≥3PN) 细胞核和胚芽细胞多核化率相关.
- 在双细胞阶段 (MN2) 的多核化可能与更高比例的≥3PN细胞母细胞有关.
研究的目的:
- 调查高比例≥3PN阳囊对常规体外受精 (C-IVF) 中MN2发病率的影响.
- 分析MN2类型与临床结果之间的关系,包括胚胎细胞形成率.
主要方法:
- 在一项针对1195名从2020年1月至2022年12月接受C-IVF治疗的患者的研究中利用时间间隔监测.
- 根据≥3PN囊胞的比例分组患者:没有 (组1),0-25% (组2) 和>25% (组3).
- 在各组中比较了MN2率,MN2类型和临床结果 (高质量的胚胎,可用的胚胎,胚芽细胞形成).
主要成果:
- 与1组和2组相比,MN2率在3组 (>25%≥3PN阴茎) 中显著更高.
- 两组之间高质量胚胎或可用胚胎的比例没有显著差异.
- 胚胎在一个芽细胞体 (2BI1) 中具有双核和在一个芽细胞体 (2MULTI1) 中具有多核的胚胎显示出比在两个芽细胞体 (2MULTI2) 中具有多核的胚胎更高的芽细胞形成率.
结论:
- MN2事件的发生率与高比例的≥3PN异构体有关.
- 特定类型的MN2 (2BI1,2MULTI1) 在分裂阶段对胚胎选择具有预后价值,以改善胚胎细胞的发育.
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